Drug Standards
Medchemexpress LLC Haloperidol | 52-86-8 | 99.8% | C₂₁H₂₃ClFNO₂ | 100 MG
This product is an analytical standard suitable for research and analytical applications. It functions as a potent antagonist for dopamine D2 receptors and is commonly employed in qualitative, quantitative, and methodological research experiments, including techniques such as HPLC, GC, and MS.
- Intended for research and analytical use.
- Dopamine D2 receptor antagonist.
- Utilized in various analytical research methods.
Selleck Chemical LLC Flavopiridol (Alvocidib) S1230-10mM/1mL
Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1 CDK2 CDK4 CDK6 and CDK9 with IC50 values in the 20-100 nM range It is more selective for CDK1 2 4 6 9 versus CDK7 Flavopiridol is initially found to inhibit EGFR and PKA Flavopiridol induces autophagy and ER stress Flavopiridol blocks HIV-1 replication Phase 1/2
Apexbio Technology LLC Bromfenac Sodium 91714-93-1 10mM (in 1mL DMSO)
Bromfenac Sodium (CAS 91714-93-1) is a nonsteroidal anti-inflammatory small molecule compound characterized primarily by its capacity to inhibit cyclooxygenase enzymes (COX-1 and COX-2) By targeting these enzymes Bromfenac Sodium disrupts prostaglandin biosynthesis subsequently modulating inflammatory pathways and responses In biomedical research Bromfenac Sodium serves as a useful pharmacological tool to investigate inflammation signaling pathways and prostaglandin-mediated processes in various experimental models
Apexbio Technology LLC Diclofenac 15307-86-5 10mM (in 1mL DMSO)
Diclofenac (CAS 15307-86-5) is a phenylacetic acid derivative classified as a non-steroidal anti-inflammatory drug (NSAID) It exerts its biological activity by inhibiting cyclooxygenase (COX)-1 and COX-2 enzymes thereby suppressing prostaglandin synthesis that mediates inflammation and pain signaling Structurally the incorporation of two ortho chlorine atoms on the phenyl ring increases molecular rigidity which has been associated with enhanced potency Diclofenac is widely used in research to study inflammatory pathways pain mechanisms and as a reference compound in the evaluation of cyclooxygenase inhibition and potential gastrointestinal protective strategies in combination therapies
Medchemexpress LLC Neratinib (Standard) | 698387-09-6 | MFCD28073539 | 99.25% | 557.04 | 50 MG
Neratinib (Standard) is the analytical standard of Neratinib, intended for research and analytical applications. It is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively. This compound is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS as a reference standard.
- Analytical standard for Neratinib.
- Intended for research and analytical applications.
- Orally available.
- Irreversible.
- Highly selective HER2 and EGFR inhibitor.
- IC50s of 59 nM for HER2 and 92 nM for EGFR.
- Used as a reference standard in HPLC, GC, and MS research experiments.
Medchemexpress LLC Curcumin-β-d-glucuronide | 227466-72-0 | MFCD28963761 | 98.0% | 544.50 | 1 ML
Curcumin-β-d-glucuronide is a major metabolite after oral intake of Curcumin, found in hepatic tissue and portal blood. It is used for research on colon cancer and has demonstrated anticancer properties in mouse tumor models and human metastatic colorectal cancer cell lines by promoting apoptosis. It also shows potential as a colon cancer prevention agent and possesses anti-inflammatory attributes by inhibiting prostaglandin E2 (PGE2) levels.
- Major metabolite of curcumin
- Exhibits anticancer properties
- Promotes apoptosis in cancer cells
- Potential colon cancer prevention agent
- Possesses anti-inflammatory attributes
- Inhibits prostaglandin E2 (PGE2) levels
Medchemexpress LLC Folic acid methyl ester | 1348988-65-7 | 99.1% | 455.42 | 5 MG
Folic acid methyl ester is a methyl ester metabolite of folic acid that can be used in the study of neuropsychiatric conditions, such as depression.
- It is a methyl ester metabolite of folic acid.
- It can be used in the study of neuropsychiatric conditions.
- It has potential application in research related to depression.
- It is available for research use only.
Medchemexpress LLC 2,6-Piperidinedione, 3-(4-bromo-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- | 2093387-36-9 | 99.86% | 323.14 | 250 MG
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, utilized in the recruitment of CRBN protein. It can be linked to a ligand for protein by a linker to create PROTACs.
- Analog of cereblon (CRBN) ligand for E3 ubiquitin ligase
- Used in the recruitment of CRBN protein
- Can be connected to form PROTACs, which are inducers of ubiquitination-mediated degradation of cancer-promoting proteins
TARGETMOL CHEMICALS INC NIRAPARIB TOSYLATE 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor. purity: 99%
Medchemexpress LLC Fluticasone propionate | 80474-14-2 | 99.93% | 200 MG
Fluticasone propionate is a potent topical anti-inflammatory corticosteroid and a selective glucocorticoid receptor agonist with an absolute affinity (KD) of 0.5 nM. It exhibits little to no activity at other steroid receptors and also possesses anti-viral activity. Its applications span immunology, anti-infection, and metabolic research.
- Potent topical anti-inflammatory corticosteroid
- Selective glucocorticoid receptor agonist (KD of 0.5 nM)
- Exhibits minimal activity at other steroid receptors
- Possesses anti-viral activity
- Inhibits TNFα-induced E-selectin expression with an IC50 of 1 nM
- Targets glucocorticoid receptor, endogenous metabolite, enterovirus, and ADC payload
- Relevant to immunology/inflammation, vitamin D related/nuclear receptor, metabolic enzyme/protease, anti-infection, and antibody-drug conjugate/ADC related pathways
Medchemexpress LLC Ciclopirox | 29342-05-0 | 98.3% | 1 ML
Ciclopirox is a synthetic, orally active antifungal agent used in research for superficial mycoses. It demonstrates broad-spectrum activity against dermatophytes, yeasts, molds, and various pathogenic bacteria, and also exhibits anticancer and anti-inflammatory effects.
- Synthetic, orally active antifungal agent
- Used for superficial mycoses research
- Exhibits broad-spectrum activity against dermatophytes, yeasts, molds, and pathogenic bacteria
- Demonstrates anticancer and anti-inflammatory effects
- Available as a 10 mM x 1 mL solution in DMSO
- Shipped at room temperature
- Powder storage: -20°C for 3 years or 4°C for 2 years
- In-solvent storage: -80°C for 2 years or -20°C for 1 year
Apexbio Technology LLC Bromhexine HCl 611-75-6 10mM (in 1mL DMSO)
Bromhexine Hydrochloride is an expectorant compound utilized frequently in respiratory research to examine mucolytic mechanisms It functions primarily by disrupting acidic polysaccharide fibers within bronchial mucus reducing mucus viscosity and facilitating mucociliary clearance The compound is routinely employed in in vitro studies involving respiratory epithelial cells and ex vivo respiratory tract tissues to investigate its pharmacological influence on mucus production and secretion Reported IC50 values for Bromhexine Hydrochloride in mucolytic assays typically range between 30-50 M under standard experimental conditions Its applications extend to the study of respiratory disorders associated with abnormal mucus secretion enabling researchers to better characterize molecular pathways involved in mucus regulation and investigate potential therapeutic targets
![Medchemexpress LLC β-Alanine, n-[[2-[[[4-(aminocarbonyl)phenyl]amino]methyl]-1-methyl-1h-benzimidazol-5-yl]carb... | 1422435-41-3 | MFCD27996084 | 50mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000267059.png-250.jpg)
Medchemexpress LLC β-Alanine, n-[[2-[[[4-(aminocarbonyl)phenyl]amino]methyl]-1-methyl-1h-benzimidazol-5-yl]carb... | 1422435-41-3 | MFCD27996084 | 50mg
Dabigatran impurity 16 is an impurity of Dabigatran (HY-10163)
Apexbio Technology LLC Isosorbide 652-67-5 10mM (in 1mL DMSO)
Isosorbide exerts its biological activity primarily through osmotic effects increasing renal water and electrolyte excretion and thereby promoting diuresis Based on these pharmacological properties isosorbide holds research potential in fluid management studies renal function modulation and in the investigation of physiological responses to altered water-electrolyte balance Additionally it serves as a molecular precursor or intermediate in pharmaceutical synthesis and biomaterial research particularly for the development of biodegradable polymers and sustained drug-delivery systems
Selleck Chemical LLC Capecitabine S1156-200mg
Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis